Shoutarou Tatewaki, a high schooler living in Asahikawa City, Hokkaido, meets Sakurako Kujou, a bone-loving young lady who has an ability to analyze specimen. Because of meeting her, he has to accompany her to various cases.Of course, there's a bit of cliche here: a brilliant and 'weird' detective that doesn't like people at all (Sakurako), and a regular person as a sidekick (Tatewaki Shoutarou). But here the detective have a singular personality trait. She REALLY likes bones, like, she's an osteologist and liked bones since she was a kid. Sakurako fancies dead humans to living ones and, at least on this first episode, this makes a difference, instead of just being used to say that the character is a cold-blooded detective.
On the other side, Shoutarou is just a regular guy (for an anime), and we still don't know how the couple became acquainted. But I think that was left for later.
One thing that I'm still wondering is what'll be the focus of the show. I don't know if it was because this was the first episode, but I loved the different approach to the usual detective/police procedural drama. Here, Sakurako uses her ability to tell that an apparent double-suicide was, in fact, a double homicide, and how she came to that conclusion. But there was no worry about finding who was the killer. It's strange but awesome at the same time, and I hope that Sakurako-san wouldn't fall into the over repeated detective drama formula.
So, if you like mysteries and detective stories and want something different from the usual formula, give Sakurako-san no Ashimoto ni wa Shitai ga Umatteiru (!) a try. Alongside the great story, it has an older protagonist, a nice change from the so common high school scenario, beautiful visuals, and it's a promising anime overall.